mepacrine hydrochloride

Giardiasis Discoid lupus erythematosus

100 mg every 8 hours for 5–7 days

Molecular weight :508.9

%Protein binding :80–90

%Excreted unchanged in urine : <11

Volume of distribution (L/kg) :Large

half-life – normal/ESRD (hrs) :5–14 days

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Unlikely to be dialysed. Dose as in normal renal function

HDF/high flux :Unlikely to be dialysed. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Alcohol: can cause a mild disulfiram reaction

Antimalarials: increased concentration of primaquine (increased risk of toxicity)

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Oral

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Still detectable in the urine after 2 months